Optimizing Choices in CLL/SLL: Strategic Approaches to Treatment Initiation and Therapy Selection in Both Initial and Refractory Disease

Treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) often begins with a period of observation. Therapy depends on signs and symptoms, as well as the patient’s quality of life. First- and second-line treatment selection depends on multiple factors; however, many oncology and/or hematology clinicians are challenged to determine when to initiate treatment or when to conduct cytogenetic and molecular testing. Patient management is complex, and will be highlighted and discussed throughout each activity within this curriculum for oncology and hematology clinicians who care for patients with CLL/SLL.