Providers/Grant Support
This activity is supported by an independent educational grant from Helsinn Therapeutics (U.S.), Inc.
Credits Available
- Physicians — maximum of 1.0 AMA PRA Category 1 Credits™
All other healthcare professionals completing this course will be issued a statement of participation.
Target Audience
This activity is designed to meet the educational needs of dermapathologists, dermatologists, medical oncologists, and oncodermatologists.
Program Overview
Join Dr. Larisa J. Geskin and leading experts for this free, on-demand, CME-accredited webcast examining the role of the tumor microenvironment (TME) in mycosis fungoides–type cutaneous T-cell lymphoma (MF-CTCL).
Explore how tumor microenvironment biology influences disease progression and therapeutic response, and how these insights can inform precision-informed treatment selection.
Introduction
Dr. Larisa J. Geskin (5 minutes)
Understanding the TME in MF-CTCL
Dr. Christiane Querfeld (15 minutes)
Cytotoxic mechanisms of skin-directed therapies
Dr. Sima Rozati (15 minutes)
Targeting tumor and microenvironment in advanced mycosis fungoides/Sezary syndrome
Dr. Francine Foss (15 minutes)
Closing remarks and Q&A
Dr. Larisa J. Geskin (10 minutes)
Learning Objectives
- Increase knowledge and confidence in interpreting MF-CTCL tumor microenvironment biology, recognizing its influence on disease progression and therapy response, and applying this understanding to guide evidence-based clinical decision-making
- Increase knowledge and confidence in evaluating the cytotoxic and immunomodulatory mechanisms of skin-directed therapies, understanding how these agents modulate the TME to reduce malignant cell burden, enhance antitumor immunity, and guide evidence-based, durable management of MF-CTCL

© 2026 Springer Healthcare LLC. Springer Health+ IME is part of Springer Nature. All rights reserved

In partnership with the United States Cutaneous Lymphoma Consortium (USCLC). This symposium was presented and recorded as part of the USCLC Annual Workshop 2026: Frontiers in Cutaneous Lymphoma: New Technologies, Therapeutics and Future Directions.
Faculty
Dr. Larisa J. Geskin, MD, FAAD
Columbia University Irving Medical Center, New York, NY, USA
Dr. Larisa Geskin is a nationally and internationally recognized expert in cutaneous oncology, specializing in the diagnosis and treatment of cutaneous lymphomas, melanoma, and complex skin cancers. She is Professor of Dermatology and Medicine at Columbia University Irving Medical Center and Director of the Cutaneous Oncology Center.
Dr. Geskin earned her medical degree and completed dermatology residency at the University of Pittsburgh School of Medicine, followed by an oncology fellowship at the University of Pittsburgh Cancer Institute. Dual-trained in dermatology and oncology, she provides comprehensive care across the full disease spectrum, including systemic chemotherapy and immunotherapy.
Over more than two decades, Dr. Geskin has led or contributed to pivotal clinical trials supporting FDA approvals of all currently approved therapies for cutaneous T-cell lymphoma (CTCL), including bexarotene, vorinostat, romidepsin, pralatrexate, denileukin diftitox, and mogamulizumab. She currently leads multiple investigator-initiated trials exploring novel treatments, including the first CAR-T therapy for T-cell lymphomas. Her work on TOX gene overexpression enabled the first molecular classification and diagnostic application in CTCL.
A physician-scientist and dedicated mentor, Dr. Geskin has authored hundreds of peer-reviewed publications, helped shape national clinical guidelines, and trained a generation of leaders in dermatologic oncology. Her honors include the Lifetime Achievement Award and Zackheim Lectureship from the U.S. Cutaneous Lymphoma Consortium, the AMA Inspiration Award, multiple ACE awards, and repeated recognition as a Castle Connolly Top Doctor. She is Past President of the International Society for Cutaneous Lymphomas, Founding Chair of the New York Cutaneous Lymphoma Consortium, and incoming President of the U.S. Cutaneous Lymphoma Consortium.
Dr. Geskin is also a leader in public health advocacy, having chaired New York State’s Skin Cancer Action Team and helped secure a statewide ban on indoor tanning for minors. She remains deeply committed to advancing patient outcomes, mentorship, and equitable, evidence-based cancer care, and values her collaborative work with colleagues at Mount Sinai to drive future discoveries for patients.
Dr. Christiane Querfeld, MD, PhD
City of Hope Comprehensive Cancer Center, Duarte, CA, USA
Christiane Querfeld, MD, PhD is a board-certified dermatologist and dermatopathologist who specializes in the diagnosis and treatment of cutaneous lymphoma. She is a Professor and Director of the Cutaneous Lymphoma Program at City of Hope Comprehensive Cancer Center and divides her time between a busy weekly clinic, her dermatopathology practice, and her research laboratory.
Dr. Querfeld’s innovative research targets both the malignancy and the surrounding cells in the tumor’s microenvironment. When activated, the immune cells in the tumor microenvironment have the capacity to kill the lymphoma cells. Her laboratory research aims to identify novel targets and advance novel strategies that both activate the immune system against cutaneous T cell lymphoma as well as direct the killing of the cancer cells to improve outcomes for patients with this challenging disease. She and her team have already developed successful, well-tolerated interventions with meaningful benefits for her patients.
Dr. Querfeld has received prestigious awards including the Clinical Scholar Career Development Award by the Leukemia & Lymphoma Society, and authored over 150 peer-reviewed articles, reviews, and book chapters in the field of cutaneous lymphoma. She has obtained extramural grants from the National Cancer Institute, Leukemia Lymphoma Society, the Israel Cancer Research Fund, and Rising Tide Foundation.
Dr. Sima Rozati, MD, PhD
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Dr. Sima Rozati is an academic dermatologist and translational investigator at the Johns Hopkins University School of Medicine, where she serves as Director of the Multidisciplinary Cutaneous Lymphoma Clinic, Co-Director of the Cutaneous Translational Research Program (CTReP), and Director of the Inpatient Dermatology Consult Service. With foundational training in both internal medicine and dermatology and advanced research training in cutaneous oncology, she brings a uniquely integrative perspective to the care of patients with complex skin disorders and cutaneous lymphomas.
Dr. Rozati has built innovative clinical, research, and educational multi-disciplinary cutaneous lymphoma program that has strengthened multi-center collaborations, and advanced mechanistic understanding of CTCL pathobiology. Through studies leveraging spatial transcriptomics, single cell RNA sequencing, systemic immune profiling, and real-world clinical cohorts, she aims to identify early biomarkers of treatment response, better understanding of immune remodeling and develop more precise, individualized therapeutic strategies.
Dr. Rozati has served as the PI or co-investigator in clinical trials that have been critical in the discovery, development, and approval of newer therapies in cutaneous T cell lymphomas. A dedicated educator and mentor, she founded the ACGME-equivalent Cutaneous Lymphoma Fellowship at Johns Hopkins and plays an active role in shaping dermatology training and research at Johns Hopkins and within national societies. Through her clinical expertise, scientific leadership, and commitment to innovation, Dr. Rozati strives to advance new therapeutic strategies and improve outcomes for patients affected by cutaneous lymphomas. She is a member of the Board of Directors of the US Cutaneous Lymphoma Consortium (USCLC).
Dr. Francine Foss, MD
Yale School of Medicine, New Haven, CT, USA
Dr. Francine Foss, Professor of Medicine in the Section of Medical Oncology at Yale Cancer Center, is an internationally recognized clinician and clinical researcher with expertise in adult lymphomas and in stem cell transplantation. She has developed and tested therapies that have been used to treat thousands of cancer patients, and her research has substantially impacted the field of stem cell research, benefiting patients at Yale and around the world. Dr. Foss has brought a nationally established clinical trials program to Yale Cancer Center. In her previous position at Tufts New England Medical Center in Boston, she designed, initiated, and directed multi-center national clinical trials which led to FDA approval of several novel therapies for lymphomas. One of these, Interleukin-2- Diphtheria toxin fusion protein, was the first FDA-approved fusion protein biologic drug and the first drug to be FDA approved for the treatment of T-cell lymphoma. In her laboratory work, she investigated and elucidated the mechanism by which extracorporeal photopheresis modulated antigen presenting cells, leading to a reduction in graft-vs-host disease in patients undergoing allogeneic stem cell transplant. These findings led to the initiation of two National Cancer Institute-sponsored trials to confirm these results in patients with lymphoma and myelodysplastic syndrome. Dr. Foss is a member of the Stem Cell Therapy clinical program at Smilow Cancer Hospital.
Dr. Foss is a world expert in T cell Lymphomas. She has pioneered several novel therapies for T cell lymphomas and has been a leader in many national studies. She developed and initiated the first national registry for T cell lymphomas in the United States and is a founder and co-chairman of the T CELL Forum, the preeminent international T cell lymphoma research meeting. She is a co-founder of the United States Cutaneous Lymphoma Consortium and currently serves as its President. She has been a Director of the international T-cell Project to research treatment and biology of T-cell lymphomas and serves on the NCCN panel of experts for T-cell lymphomas. As a translational researcher in T cell Lymphomas, she currently is collaborating with a number of laboratories and scientists at Yale to identify molecular targets in T Cell Lymphoma and recently was awarded a grant through the PITCH program for the state of Connecticut to develop a promising small molecule therapeutic for a rare form of lymphoma. Dr. Foss currently leads the multi-disciplinary T-cell Lymphoma clinical team at the Smilow Cancer Center and co-directs the Cutaneous Lymphoma Program at Yale with Dr. Michael Girardi. Her clinical practice at Smilow Cancer Hospital attracts patients from around the world.
Accreditation Statement

In support of improving patient care, this program has been planned and implemented by the Postgraduate Institute for Medicine and Springer Health+ IME. The Postgraduate Insititute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.
Credit Designation

The Postgraduate Institute for Medicine designates this enduring material for a maximum of 1.0 AMA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.
Disclosures of Conflicts of Interest
Dr. Larisa J. Geskin
- Grant/Research support: Helsinn, Therakos
- Consultant/Advisory board: Helsinn, Regeneron, Sanofi, SciTech
- Non-mutual funds stock ownership/Stock options: Celsyntec
Dr. Christiane Querfeld:
- Grant/Research support: Kyowa Kirin
- Consultant/Advisory board: Citius Pharmaceuticals, Helsinn, Kyowa Kirin, SLAM Biotherapeutics
Dr. Sima Rozati:
- Grant/Research support: Kyowa Kirin
- Consultant/Advisory board: Kyowa Kirin, Secura Bio, Therakos
Dr. Francine Foss:
- Speakers bureau/Honoaria for non-CME: Acrotech, Kyowa, Pfizer, Secura
- Consultant/Advisory board: Citius
Instructions for Participation and Credit
There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:
- Read the CME/CE information and faculty disclosures.
- Participate in the online activity.
- Submit the evaluation form.
Certificates will be immediately available to the participant.
Disclosure of Unlabeled Use
Faculty participating in any CME activity are required to disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States. For CME questions please contact: [email protected]
Disclaimer
This activity is designed for educational purposes for healthcare professionals only. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.
Contact Information
For CME questions please contact: [email protected]