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A1375 Free CME 960x95

Released

September 19, 2025

Expires

March 31, 2026

Media Type

Internet

Completion Time

60 minutes

Specialty

Ophthalmology

Topic

Retinal Disease

Educational Provider

This activity is provided by Paradigm Medical Communications, LLC

Paradigm Logo

Supporter Acknowledgment 

This activity is supported by an educational grant from Genentech, a member of the Roche Group.

Credits Available

  • Physicians — maximum of 1.0 AMA PRA Category 1 Credit
  • Physician Assistants – may claim a maximum of 1.0 Category 1 Credit for completing this activity
  • Nurse Practitioners –may claim a maximum of 1.0 Category 1 Credit for completing this activity

All other healthcare professionals completing this course will be issued a statement of participation.

Target Audience

This activity has been designed to address the educational needs of retina specialists, ophthalmologists, and other clinicians who are interested in the management of patients with neovascular retinal disease.

Program Overview

Recent research has uncovered clinical biomarkers of neovascular retinal disease (beyond neovascularization) that may be useful in instructing individualized treatment choice and retreatment decisions in the era of second-generation therapy. Join renowned experts as they present the latest evidence illuminating the role of angiopoietin-2 (Ang-2) in disease pathophysiology and the effects of dual Ang-2/vascular endothelial growth factor (VEGF) inhibition on clinical biomarkers of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) that can be visualized in the clinic.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Explain the role of elevated Ang-2 in the pathophysiology of neovascular retinal diseases
  • Differentiate the effects of dual inhibition therapy and anti-VEGF therapy on clinical biomarkers of DME
  • Compare the impact of dual inhibition therapy and anti-VEGF therapy on clinical biomarkers of nAMD
  • Individualize treatment for patients with neovascular retinal disease based on clinical biomarkers of disease activity

Faculty

Roger A. Goldberg, MD, MBA

Vitreoretinal Specialist
Partner, Bay Area Retina Associates
Walnut Creek, CA
Volunteer Faculty
California Pacific Medical Center 
Ophthalmology Residency
San Francisco, CA

T.Y. Alvin Liu, MD

James P. Gills Jr MD and Heather Gills Rising Professor of Artificial Intelligence in Ophthalmology
Inaugural Director, James P. Gills Jr MD and Heather Gills Artificial Intelligence Innovation Center 
AI Oversight Team
Co-Chair (imaging), AI and Data Trust Council
Johns Hopkins Medicine
Baltimore, MD

Physician Accreditation Statement

Paradigm Medical Communications, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physician Credit Designation Statement
Paradigm Medical Communications, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

PA Continuing Education
PAs may claim a maximum of 1.0 Category 1 credit for completing this activity. NCCPA accepts AMA PRA Category 1 Credit from organizations accredited by ACCME or a recognized state medical society.

Nurse Practitioner Continuing Education 
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Disclosures of Relevant Financial Relationships

In accordance with the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education, Paradigm requires that all planners, faculty, and others who are in a position to control the content of this activity disclose all financial relationships with ineligible companies during the past 24 months.

All relevant relationships are identified and mitigated according to Paradigm policy prior to individuals assuming their roles and are disclosed prior to learners’ engagement in the activity. Paradigm is committed to providing learners with high-quality accredited continuing education that promotes improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company. 

The content of this activity was independently reviewed to ensure that it is fair and balanced, scientifically rigorous, evidence based, and aligned with the public interest. All relevant relationships have been mitigated. 

Roger A. Goldberg, MD
Consultant: AbbVie Inc.; Alimera Sciences; Annexon, Inc; Apellis Pharmaceuticals, Inc; Boehringer Ingelheim International GmbH; Clearside Biomedical; EyePoint Pharmaceuticals, Inc; Genentech, Inc.; Janssen Pharmaceuticals, Inc; Neurotech Pharmaceuticals, Inc; Ocular Therapeutix, Inc; ORASYS LLC; Stealth BioTherapeutics Inc; Regeneron Pharmaceuticals Inc; ZEISS International
Speakers’ Bureau: Apellis Pharmaceuticals, Inc; Biogen (expired 2023); Genentech, Inc.
Research Funding: 4D Molecular Therapeutics; AbbVie Inc; AffaMed Therapeutics; Alexion Pharmaceuticals, Inc; Apellis Pharmaceuticals, Inc; Annexon, Inc; Avirmax Inc; Boehringer Ingelheim International GmbH; Clearside Biomedical; Cognition Therapeutics; EyePoint Pharmaceuticals, Inc; Genentech, Inc.; Janssen Pharmaceuticals, Inc; Neurotech Pharmaceuticals, Inc; Novo Nordisk A/S; OcuTerra Therapeutics (expired 2023); Ocular Therapeutix; Stealth BioTherapeutics Inc; Regeneron Pharmaceuticals Inc; UNITY Biotechnology; ZEISS International
Stocks: Emmetrope Ophthalmics

T.Y. Alvin Liu, MD
Advisor: Optain Health
Consultant: FerRx Bio
Speakers’ Bureau: OMNY, Inc. 
Research Funding: Amaros, Inc.

Peer Reviewer
Stocks: CytomX Therapeutics Inc (expired 1/25); F. Hoffmann-La Roche Ltd (expired 3/24); Medtronic (expired 3/24); Pfizer Inc. (expired 3/24)
 

Paradigm Medical Communications, LLC staff members have no relevant financial relationships with ineligible companies to disclose.

Instructions for Participation and Credit

To receive a certificate and claim credit, participants must:

  • Follow instructions to register or log in with your professional information and complete the pretest
  • View the online activity in its entirety
  • Complete and submit the online posttest and evaluation. You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the posttest

A certificate of participation will be available for download/printing immediately following your successful completion of the posttest and evaluation.

For questions regarding CME credit, contact the Paradigm CME Department at [email protected].

There are no fees for participating in this activity.

Course Viewing Requirements

Hardware/Software Requirements
This accredited CME activity is designed using HTML5 web components. As you navigate the video using the supplied controls, the slides will sync to the speaker.

Supported Browsers (Desktop/Mobile)
Chrome 45+, Firefox 40+, Edge, Edge Chromium, Safari 8+, Opera 31+

PDF documents
This activity may contain PDF documents. Most current browsers support viewing of PDFs natively, but you may also download a free version of Adobe Acrobat Reader here: http://get.adobe.com/reader

Technical Support: If you have any technical problems or playback issues, email us at [email protected].

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA.

Disclaimer

This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion, and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

If included, signed statements of informed consent granting permission for publication have been obtained for all photographs and videos in which an individual can be identified.

As an ACCME-accredited provider, Paradigm Medical Communications, LLC must ensure that its activities include a balanced view of therapeutic options. Use of generic names contributes to this impartiality. The use of trade names should not be viewed as an endorsement of specific products by Paradigm Medical Communications, LLC.

Terms of Use and Privacy Policy

Disclaimer
The materials provided for this activity are for informational purposes only and should not be used for diagnosis or treatment of a health problem without consulting a licensed medical professional. This CME activity represents the views and opinions of the individual faculty, and does not constitute the opinion or endorsement of, or promotion by, Paradigm Medical Communications, LLC. References to any entity, product, service, or source of information on this website should not be considered an endorsement, either direct or implied, by Paradigm Medical Communications, LLC. Paradigm Medical Communications, LLC accepts no liability for the content referenced in this activity.

Privacy policy
Paradigm Medical Communications, LLC or hosted contracted partner is committed to protecting the privacy of those who participate in the activities located at www.paradigmmc.com (herein referred to as “website”). The information below describes the security of the website for safeguarding personal information and the rationale for collection and use of personal information.

Security/safeguarding personal information
This website has physical and procedural safeguards in place to prevent unauthorized access to personal information used to access this website.

Collection and use of your personal information
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing the program. Required items include first name, last name, degree, and email address. These items are necessary. Participants are also required to complete an evaluation of the CME activity. All evaluative information submitted is collected and retained, and used by Paradigm Medical Communications, LLC to continuously improve the learning experience.

Paradigm Medical Communications, LLC does not transfer, sell, or share personal information with outside parties. Paradigm Medical Communications, LLC will not otherwise disclose personal information unless required to in a legal process. Paradigm Medical Communications, LLC staff members review individual test results to the extent necessary to record and track participants’ credits.

Contact Information

If you have any questions or comments, please email us at [email protected]

© 2025 Paradigm Medical Communications, LLC except where noted. Content may not be reproduced in whole or part without the express written permission of Paradigm Medical Communications, LLC.