Providers/Grant Support
This activity is supported by an educational grant from Chiesi USA.
Credits Available
- Physicians — maximum of 0.75 AMA PRA Category 1 Credit™
- Physician Associates — 0.75 AAPA Category 1 CME Credit
- Nurses — 0.75 Nursing Contact Hour (including 0.5 pharmacology hour)
- Pharmacists — 0.75 Contact Hour (0.075 CEU)
All other healthcare professionals completing this course will be issued a statement of participation.
Target Audience
This activity was developed for geneticists, metabolic disease specialists, pediatricians, physician associates, nurse practitioners, nurses, genetic counselors, and pharmacists who care for patients with lysosomal storage disorders.
Program Overview
Alpha‑mannosidosis (AM) is a rare, progressive lysosomal disorder with a broad and heterogeneous clinical phenotype that can evolve across the lifespan. Drawing on the 2024 Global Delphi Consensus Recommendations and other recent evidence, this activity focuses on practical, clinician‑oriented strategies for baseline and longitudinal assessment, use of enzyme replacement therapy and hematopoietic stem cell transplantation, monitoring treatment response and disease progression, and the coordination of interprofessional, multidisciplinary care essential for patient management.
Learning Objectives
Upon completion of this activity, participants should be better able to:
- Identify the characteristics and clinical presentation of alpha-mannosidosis that should prompt a referral to a specialist
- Develop patient-specific ERT treatment regimens that align with current best practices to achieve optimal patient outcomes
- Apply recommended strategies for incorporating HSCT, supportive care, and integrated team-based care for patients with alpha-mannosidosis
Faculty
Laura D. Buch, MSPAS, PA-C
Genetics Physician Associate
Greenwood Genetic Center
Greenville, South Carolina
Barbara K. Burton, MD
Professor of Pediatrics
Northwestern University Feinberg School of Medicine
Chicago, Illinois
Accreditation Statement
In support of improving patient care, Annenberg Center for Health Sciences at Eisenhower (Annenberg Center) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Credit Designation
Physician Credit
The Annenberg Center designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physician Associate Credit
The Annenberg Center has been authorized by the American Academy of Physician Associates (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.75 AAPA Category 1 CME credit. Approval is valid until March 12, 2027. PAs should only claim credit commensurate with the extent of their participation.
Pharmacist Credit
The Annenberg Center designates this knowledge-based activity for a maximum of 0.75 hour. Credit will be provided to NABP CPE Monitor within 45 days after the activity completion.
Nurse Credit
The Annenberg Center designates this education for a maximum of 0.75 American Nurses Credentialing Center (ANCC) contact hour, including 0.5 pharmacology hour.
Provider is approved by the California Board of Registered Nursing, Provider #13664, for 0.75 contact hour. To receive credit for education contact hours outside of the state of California, please check with your state board of registered nursing for reciprocity.
Disclosures of Conflicts of Interest
Disclosure Statement
It is the policy of the Annenberg Center to ensure fair balance, independence, objectivity, and scientific rigor in all programming. All individuals with the potential to impact the content of an accredited education activity are expected to identify and reference off-label product use and disclose relevant financial relationships with ACCME-defined ineligible companies.
The Annenberg Center assesses relevant financial relationships with its instructors, planners, managers, and other individuals who are in a position to control the content of CE activities. All relevant financial relationships that are identified are mitigated by the Annenberg Center for fair balance, scientific objectivity of studies utilized in this activity, and patient care recommendations. The Annenberg Center is committed to providing its learners with high-quality CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.
Laura D. Buch, MSPAS, PA-C
Advisory Board – Amicus
Speakers Bureau – Chiesi, Sanofi
Barbara K. Burton, MD
Consultant – Alltrna, Alexion, Applied Therapeutics, Denali, Moderna, Takeda, Uniqure, Ulatragenyx
Speakers Bureau – Alexion, BioMarin
Additional content planners
The following have no relevant financial relationships to disclose:
Austin Ulrich, PharmD, BCACP (Medical Writer)
Amber Lambert, DNP, FNP-C (Nurse Reviewer)
Instructions For Participation and Credit
There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:
- Read the CME/CE information and faculty disclosures.
- Participate in the online activity.
- Submit the evaluation form.
Certificates will be available for the participant to download.
Course Viewing Requirements
Supported Browsers:
Desktop: Newest and last prior version of Google Chrome, Firefox, Safari, and Microsoft Edge
Mobile devices: Newest and last prior version of Safari and Google Chrome
Supported Phones & Tablets:
All devices
Disclosure of Unlabeled Use
The faculty for this activity has disclosed that there will be discussion about the use of products for non-FDA approved indications.
Disclaimer
This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.
Contact Information
For CME questions please contact: [email protected]