Providers/Grant Support
This educational activity is jointly provided by American Academy of Allergy, Asthma & Immunology.
in collaboration with RealCME.
This activity is supported by an education grant from Regeneron.
Credits Available
- Physicians — maximum of 0.25 AMA PRA Category 1 Credit™
All other healthcare professionals completing this course will be issued a statement of participation.
Target Audience
Allergy, Immunology and Pulmonology clinicians (MDs, DOs and APPs)
Program Overview
Biologic therapies targeting IgE, IL-5, IL-4Rα, and TSLP have reshaped the landscape for severe asthma, allowing for personalized, phenotype-driven care. These agents offer options for patients who remain symptomatic despite maximal inhaled therapy. Several biologics are currently approved, with dupilumab and tezepelumab among the most recent additions. This expanded toolkit offers flexibility in treatment selections, yet it can also make decisions more complicated for asthma specialists and primary care providers alike.
Specialists, including allergists and pulmonologists, lead in diagnosing complex cases, conducting phenotyping, and initiating biologic therapy. However, they are often unsure how to choose among the available biologics, particularly when indications overlap, or patient profiles vary. Questions also remain around when to switch agents, taper therapy, or apply biomarker data to personalize long-term care.
This curriculum has been developed for asthma specialists and will focus on optimizing the use of biomarkers and treatment algorithms to personalize biologic selection, sequencing, and de-escalation strategies in complex or refractory asthma cases.
Learning Objectives
After completing this activity, participants should be better able to:
- APPLY case-based strategies to switch between biologics, therapy or personalize long-term management based on treatment response, biomarker trends, and comorbid conditions.
Faculty
Karla E. Adams, MD, FAAAAI, FACAAI, FAAP
Professor of Pediatrics
Uniformed Services University
Bethesda, MD
Program Director, Allergy and Immunology Fellowship
Wilford Hall Ambulatory Surgical Center
Lackland Air Force Base, TX
Dr. Karla Adams is a Professor of Pediatrics and a practicing Allergist in San Antonio, Texas. She obtained her medical degree from the Uniformed Services University then completed a Pediatrics residency and Allergy and Immunology Fellowship at the San Antonio Uniformed Services Health Education Consortium in San Antonio, TX. She is currently the Program Director for the Allergy and Immunology Fellowship at Wilford Hall Ambulatory Surgical Center, San Antonio, TX.
Juan Carlos Cardet, MD, MPH
Associate Professor of Medicine and Pediatrics
University of South Florida
Division of Allergy and Immunology
Department of Internal Medicine
Tampa, FL
Juan Carlos Cardet, MD, MPH received his BS degree from Harvard University, Cambridge, Massachusetts in 2004; medical degree from the University of Puerto Rico, San Juan, Puerto Rico in 2008; and master’s in public health degree from Harvard University, Boston, Massachusetts in 2017. He completed his internal medicine training at the University of Connecticut in 2011, where he was given the Maxwell O. Phelps, M.D. award for scholarship, and the Hartford Hospital Outpatient Clinic Resident of the Year Award. He completed his Allergy and Immunology training at Brigham and Women’s Hospital/Harvard University in 2014. He served as an instructor in medicine at Harvard Medical School, and as the assistant director of the Asthma Research Center at Brigham and Women’s Hospital from 7/2014—6/2017.
Dr. Cardet specializes in the treatment of patients with asthma and other allergic and immunologic diseases. He is board certified in Allergy and Immunology, and he is a fellow of the American Academy and College of Allergy Asthma and Immunology (AAAAI and ACAAI). He is the chair of the Allergy and Asthma in Older Adults committee and secretary of the Asthma Diagnosis and Treatment interest section of the AAAAI.
His work focuses on mechanisms-based therapeutics for allergic and immunologic diseases. He conducts clinical and translational research and has been awarded NIH K23, R21 and U awards as well as several industry-sponsored and foundation grants for his projects.
Puneet Shroff, MD, FAAAAI, FACAA
Clinical Associate Professor, Medicine
University of Arizona College of Medicine
Associate Clinical Director, Allergy Clinic
Banner University Medical Group
Tucson, AZ
Dr. Puneet Shroff is a board-certified Allergist & Immunologist who joined the University of Arizona in the Division of Pulmonary, Allergy, Critical Care & Sleep Medicine in 2018. He is also a Clinical Associate Professor of Medicine. Dr. Shroff came to Tucson after having built a thriving Allergy & Immunology practice in Houston from 2012 to 2018. He has a keen clinical acumen and a deep understanding of allergy clinic workflow, including allergy testing and immunotherapy. During his time in Houston, Dr. Shroff also served on the Board of the Greater Houston Allergy, Asthma & Immunology Society.
Dr. Shroff received his Doctor of Medicine in Chicago, IL and then completed residency in Internal Medicine at Washington University in St. Louis. He then trained at Baylor College of Medicine in Houston, TX where he completed a dual fellowship in Allergy & Immunology and Rheumatology and served as Chief Fellow. Dr. Shroff has studied internationally, including the University of Oxford, and he is a Certified Instructor in Yoga, including asana and pranayama (breathing) practices. He also has additional training in Integrative Medicine through the Arizona Center for Integrative Medicine founded by Dr. Andrew Weill.
Technical Writer
Lynne Kolton Schneider, PhD
Reviewer
Jordana Goldman, MD
Accreditation Statement
This activity is accredited through AAAAI.
CME: The American Academy of Allergy Asthma and Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
CE: The American Academy of Allergy Asthma and Immunology (AAAAI) is a Provider approved by the California Board of Registered Nursing, Provider #10704
Credit Designation Statement
The AAAAI designates this activity for up to 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosure of Financial Relationships Policy
AAAAI adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME/CE activity, including faculty, planners, reviewers, or others are required to disclose all financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.
Disclosures
Dr. Adams has no relevant disclosures
Dr. Cardet has the following relevant relationships: Aiolosbio, Amgen, Apogee, AstraZeneca, Chiesi, Genentech, Sanofi (advisory board)
Dr. Shroff has no relevant disclosures
Lynne Kolton Schneider, PhD, has no relevant disclosures
Jordana Goldman, MD, has no relevant disclosures
Disclaimer
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of AAAAI and RealCME. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
If you have any questions relating to the accreditation of this activity, please contact [email protected]
Participation and Credit
Please proceed with the activity until you have successfully completed this program, answered all test questions, and evaluation, and have received a digital copy of your credit certificate.P
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