Clinical Treatment Scenarios: Vitiligo Pathogenesis and the Role of JAK Inhibition – An In the Clinic Activity
October 24, 2023
October 24, 2024
This activity is provided by Integrity Continuing Education, Inc.
This activity is supported by an educational grant from Incyte Corporation.
- Physicians — maximum of .75 AMA PRA Category 1 Credit™
All other healthcare professionals completing this course will be issued a statement of participation.
This educational activity has been designed to meet the needs of dermatologists, family practice physicians, nurse practitioners, physician assistants, and other clinicians who manage patients with vitiligo.
“If you’ve seen one patient with vitiligo…you’ve seen one patient with vitiligo,” vitiligo expert Dr. David Rosmarin is fond of saying. This relatively common dermatologic disorder can present in a wide variety of ways and its impact on patients’ quality of life can be profound yet highly individual. As the pathogenesis of vitiligo began to reveal itself, it became clear that this autoimmune inflammatory disease is medical, not cosmetic, and can be managed by blocking aberrant signaling through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. However, until July 2022, there was no FDA-approved treatment that could accomplish this and restore the pigment lost to the destruction of melanocytes on the face, hands, or anywhere on the body. There is now a new treatment, ruxolitinib cream 1.5%, approved for use by adolescents and adults with nonsegmental vitiligo of any severity and in all parts of the body.
Join Dr. Rosmarin as he presents information about this and other emerging JAK inhibitors and offers ideas and treatment recommendations for case study patients that are likely to resemble, but not replicate, your highly individual patients with vitiligo.
Upon completion of this activity, participants should be able to:
- Improve clinicians’ knowledge of the pathogenesis of vitiligo
- Describe the role of the JAK/STAT pathway in vitiligo
- Recall clinical trial data for new and emerging therapies for vitiligo
David Rosmarin, MD
Chair of Dermatology
Indiana University School of Medicine
Physician Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physician Credit Designation
Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosures of Relevant Financial Relationship(s)
Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.
The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:
- David Rosmarin, MD
- Consultant: AbbVie, Abcuro, AltruBio, Arena, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Concert, CSL Behring, Dermavant, Dermira, Incyte, Janssen, Kyowa Kirin, Lilly, Novartis, Pfizer, Recludix, Regeneron, Revolo Biotherapeutics, Sanofi, Sun Pharma, UCB, Viela Bio
- Research: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermira, Galderma, Incyte, Janssen, Lilly, Merck, Novartis, Pfizer, Regeneron
- Speaker: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermavant, Incyte, Janssen, Lilly, Novartis, Pfizer, Regeneron, Sanofi
The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.
Instructions for Participation and Credit
There are no fees for participating and receiving CME credit for this activity. During the period of May 15, 2023 through May 15, 2024, participants must:
- Read the learning objectives
- Complete the pretest
- Study the educational activity
- Complete the posttest and the evaluation form
A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 55% or better.
Course Viewing Requirements
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above
Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.
For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or [email protected].