Transfusion-Related Iron Overload–Evidence-Based Approaches to Improve Chelation Outcomes
December 22, 2022
December 22, 2023
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This activity is provided by Physicians’ Education Resource®, LLC.
This activity is supported by an educational grant from Chiesi USA.
- Physicians — maximum of 2.5 AMA PRA Category 1 Credits™
All other healthcare professionals completing this course will be issued a statement of participation.
This educational activity is directed toward hematologists. Pediatricians, nurses, nurse practitioners, physician assistants, and other clinicians involved in the management of patients with iron overload are also invited to attend.
Patients who require ongoing red blood cell transfusions, such as individuals with transfusion-dependent thalassemia or sickle cell disease, may develop iron overload. Severe or long-term iron overload can result in a higher risk of a variety of complications, including hepatic dysfunction, heart failure and arrhythmias, and endocrine complications.
In this program, experts take learners through a comprehensive review of transfusion-related iron overload, taking a deep dive into the optimal use of chelation therapy, with specific approaches to patients with sickle cell disease and thalassemia major.
This educational activity is an archive of the live virtual presentation held on December 9, 2022.
- Upon completion of this activity, participants should be better able to:
- Outline the pathophysiologic effects of iron overload at a cellular level
- Identify end-organ effects from excess iron in transfusion-dependent patients
- Apply appropriate testing modalities to assess iron status in patients with transfusion-dependent iron overload
- Develop optimal care plans for patients with iron overload based on clinical presentation and goals of therapy
Trisha E. Wong, MD, MS
Department of Pathology, Transfusion Medicine
Department of Pediatrics, Hematology/Oncology
Director of Pediatric Transfusion Medicine
Director of Hemoglobinopathies
Oregon Health & Science University
Ross M. Fasano, MD
Associate Professor, Pathology/Laboratory Medicine and Pediatrics
Emory University School of Medicine
Program Director of Emory Transfusion Medicine Fellowship
Hematologist, Aflac Cancer & Blood Disorders Center
Children’s Healthcare of Atlanta
Hematologist, Georgia Comprehensive Sickle Cell Center at Grady Health System
John C. Wood, MD, PhD
Professor of Pediatrics and Radiology
Children’s Hospital Los Angeles
Los Angeles, CA
Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physicians’ Education Resource®, LLC, designates this enduring material for a maximum of 2.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Faculty, Staff, and Planners’ Disclosures
The staff of Physicians’ Education Resource®, LLC have no relevant financial relationships with ineligible entities.
- Trisha E. Wong, MD, MS
- Other Support: One-time honorarium from DisperSol Technologies from March 2022.
- Ross M. Fasano, MD
- Other Support: I have given educational talks (paid) by Terumo (maker of apheresis machines).
- John C. Wood, MD, PhD
- Grant/Research Support: Philips Healthcare
- Consultant: Agios Pharmaceuticals, Bristol Myers Squib, Celgene, Imago BioSciences, Pharmacosmos, Regeneron, Vifor Pharma
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Instructions for Participation and Credit
- Complete the activity (including pre- and post-activity assessments).
- Answer the evaluation questions.
- Request credit using the drop-down menu.
Course Viewing Requirements
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above
Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.