By David Rakel, MD
Associate Professor, Department of Family Medicine; Founder and Director, University of Wisconsin Integrative Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI
Dr. Rakel reports no financial relationships relevant to this field of study.
Synopsis: A whole foods, antioxidant-rich supplement attenuated the rise of PSA in men with localized prostate cancer.
Source: Thomas RJ, et al. A double-blind, placebo RCT evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer: The U.K. National Cancer Research Network (NCRN) Pomi-T study. J Clin Oncol 2013 (suppl; abstr 5008).
In this study, 203 men with localized prostate cancer, being managed by observation, were randomized to receive a capsule containing a blend of pomegranate seed, green tea, broccoli, and turmeric or placebo for 6 months. Baseline characteristics between the two groups were identical and matched for confounding variables, except for average age (71.8 years in the supplement group, 76.4 years in the placebo group). During the study, the median rise in prostatic specific antigen was 14.7% in the supplement group vs 78.5% in the placebo group (P = 0.0008); more men in the supplement group were retained in the "watchful waiting" treatment approach, rather than more aggressive therapy. These results agree with other recent research about the anticancer effects of these "superfoods," this time as a blend of nutrients.