SYNOPSIS: A retrospective data analysis from the UK clinical practice research datalink finds that hypoglycemia in patients treated for diabetes increases the risk of cardiovascular disease and all-cause mortality.
SOURCE: Khunti K, et al. Hypoglycemia and risk of cardiovascular disease and all-cause mortality in insulin-treated people with type 1 and type 2 diabetes: A cohort study. Diabetes Care 2015;38:316-322.
This data analysis conducted by the UK Clinical Practice Research Datalink covers 265,868 insulin-treated patients 30 years and older that were diagnosed with diabetes between 2001 and 2007. 3260 of those examined were diagnosed with T1DM while 10,422 had T2DM. During the median follow-up periods of 5 years for type 1 patients and 4.8 years for type 2, 573 (18%) and 1463 (14%) of patients respectively, experienced hypoglycemia. In comparisons with the control (non-hypoglycemic) group, T1DM patient’s hazard ratio for cardiovascular events was 1.51 for those with a history of cardiovascular disease, and 1.61 for those without a history of CVD. For patients with T2DM, their respective hazard ratios were 1.60 and 1.49. For all diabetes patients, the median time interval between the first cardiovascular event and the first hypoglycemia event that preceded it was 1.5 years. Hypoglycemia then, increases diabetes patients’ risk of both cardiovascular disease and of all-cause mortality.